![]() ![]() Two independent reviewers extracted the data and assessed the quality of included studies using the AMSTAR-2, an adapted AMSTAR-2, or the STREGA for a large genetic study. Studies of depression associated with physical conditions and specific subtypes of depression (e.g. Systematic reviews, meta-analyses and large data-set analyses in the following areas were identified: serotonin and serotonin metabolite, 5-HIAA, concentrations in body fluids serotonin 5-HT 1A receptor binding serotonin transporter (SERT) levels measured by imaging or at post-mortem tryptophan depletion studies SERT gene associations and SERT gene-environment interactions. PubMed, EMBASE and PsycINFO were searched using terms appropriate to each area of research, from their inception until December 2020. ![]() ![]() We aimed to synthesise and evaluate evidence on whether depression is associated with lowered serotonin concentration or activity in a systematic umbrella review of the principal relevant areas of research. The serotonin hypothesis of depression is still influential. ![]()
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